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Investigating the causes of stillbirth

Project Status In Progress
Organisation Lead Stillbirth CRE
Lead Investigators Vicki Flenady
Ms Tania Marsden
Program Area Data To Drive Change
Topic Improving Data Capture To Prevent Stillbirth In Australia
Contact Ms Tania Marsden

This suite of studies forms the major component of PhD thesis for Tania Marsden.

In this study we identified causes of stillbirths in a large well-investigated cohort and improve the quality of data on stillbirths across Australia through identifying a cost-effective, evidence-based approach to stillbirth investigations.

Specific aims are:

  • To describe the causes and contributing factors to stillbirth in a well investigated cohort.
  • To evaluate the procedures involved in establishing and maintaining a stillbirth research data collection system, including independent expert panel review, compliance with Perinatal Society of Australia and New Zealand (PSANZ) stillbirth investigation protocol and data quality
  • To determine agreement between hospital review committees and the expert panel with regards to classification of causes of stillbirth using the PSANZ Perinatal Death Classification (PDC).
  • To determine the clinical utility of stillbirth investigations.
  • To determine the reporting practices of perinatal autopsies and placental pathology in stillbirths.

Research team: Jessica Sexton, Mu Cheng, Jane Dahlstrom, Yee Khong, Fran Boyle, Michael Coory, Vicki Flenady, David Ellwood.

Affiliation

  1. Mater Research Institute, University of Queensland, Australia
  2. Consultant Pathologist, ACT Pathology, Canberra Health Services, Canberra, Australia
  3. School of Medicine and Psychology, College of Science and Medicine, Australian National University, Canberra, Australia
  4. Consultant Pathologist, SA Pathology, Women’s and Children’s Hospital; Adelaide, Australia.
  5. Professor Obstetrics and Gynaecology, Griffith University and Director of Maternal-fetal Medicine, Gold Coast University Hospital Gold Coast, Australia

Publications:

Sexton JK, Mahomed K, Marsden T, Coory M, Gardener G, Ellwood D, et al. Prospective cohort study: Causes of stillbirth in Australia 2013–2018. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2021;61(5):667-74.

Marsden T, Khong TY, Dahlstrom JE, Ellwood D, Moghimi A, Prystupa S, et al. Validation of a tool for determining the clinical utility of stillbirth investigations. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2023;63(4):535-40.

Marsden T, Shukralla H, Khong TY, Dahlstrom JE, Flenady V, Sexton J. Understanding the clinical utility of stillbirth investigations: a scoping review. BMC Pregnancy and Childbirth. 2025;25(1):221.

Western Pacific Regional Office of the International Stillbirth Alliance
Coordinating Centre, Stillbirth and Neonatal Death Alliance, Perinatal Society of Australia and New Zealand

Level 3, Aubigny Place
Mater Research Institute
Raymond Terrace,
South Brisbane QLD 4101
The University of Queensland Faculty of Medicine

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